Description

Ethyl 4,4,4-Trifluorobut-2-Enoate is a versatile fluorinated building block and ester derivative, valued for its unique trifluoromethyl-substituted alkene functionality. This compound is essential for introducing the trifluoromethyl group into target molecules, a modification known to significantly enhance metabolic stability, lipophilicity, and bioavailability. It is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in synthesis and R&D.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of active pharmaceutical ingredients (APIs), particularly those requiring a trifluoromethyl moiety to optimize drug-like properties.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the CF3 group improves biological activity and environmental persistence.
• Material Science: Serves as a monomer or precursor for synthesizing fluorinated polymers and specialty materials with enhanced chemical resistance and thermal stability.
• Organic Synthesis Building Block: Employed in Michael additions, cycloadditions, and other C-C bond-forming reactions to construct complex fluorinated organic molecules.
• Liquid Crystal & OLED Research: Acts as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes.
• Cross-Coupling Reactions: A suitable substrate for palladium-catalyzed reactions, such as Heck couplings, to create diverse fluorinated scaffolds.

Basic Information

Product Name	Ethyl 4,4,4-Trifluorobut-2-Enoate
CAS No.	406-10-0
Molecular Formula	C6H7F3O2
Molecular Weight	168.11 g/mol
Synonyms	Ethyl 4,4,4-Trifluoro-2-butenoate; 4,4,4-Trifluorocrotonic Acid Ethyl Ester; 2-Butenoic acid, 4,4,4-trifluoro-, ethyl ester; Ethyl (E)-4,4,4-Trifluorobut-2-enoate; Ethyl 4,4,4-Trifluorocrotonate; Trifluorocrotonic Acid Ethyl Ester; ETFB
EINECS	Contact for details

Quality Control

Our Ethyl 4,4,4-Trifluorobut-2-Enoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place away from heat sources and incompatible materials such as strong acids and bases. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature: 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index	1.380 - 1.390
Density	1.25 - 1.35 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.