Description

4-(Trifluoromethyl)Anisole is a versatile fluorinated aromatic building block, characterized by the presence of both a methoxy group and a trifluoromethyl group on the benzene ring. This unique structure imparts valuable properties such as enhanced lipophilicity and metabolic stability, making it a critical intermediate in advanced chemical synthesis. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of novel drug candidates, particularly in medicinal chemistry for CNS and oncology targets.
• Agrochemical Synthesis: Used in the manufacture of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for display technologies.
• Organic Electronics: Employed in the development of organic semiconductors and charge-transport materials due to its electron-withdrawing characteristics.
• Specialty Polymer Modifier: Incorporated to impart specific properties like chemical resistance or altered refractive index in high-performance polymers.
• Chemical Research & Development: A valuable reagent for exploring new fluorination methodologies and constructing complex molecular architectures in academic and industrial R&D.

Basic Information

Product Name	4-(Trifluoromethyl)Anisole
CAS No.	402-52-8
Molecular Formula	C8H7F3O
Molecular Weight	176.14 g/mol
Synonyms	p-(Trifluoromethyl)anisole; 1-Methoxy-4-(trifluoromethyl)benzene; 4-Methoxybenzotrifluoride; 4-Methoxy-α,α,α-trifluorotoluene; 4-Trifluoromethylphenyl methyl ether; Anisole, 4-(trifluoromethyl)-; p-Methoxybenzotrifluoride; p-Trifluoromethylanisole
EINECS	206-943-5

Quality Control

Our 4-(Trifluoromethyl)Anisole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material meets the stringent requirements for pharmaceutical and advanced chemical synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and oxidizing agents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20/D)	1.440 - 1.445
Density (20°C)	1.25 - 1.30 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.