Description

2-Chloro-5-(Trifluoromethyl)Anisole is a versatile halogenated aromatic ether building block of significant importance in advanced organic synthesis. Its value lies in the unique combination of a methoxy group and chlorine/trifluoromethyl substituents, which allows for selective functionalization and introduces desirable physicochemical properties into target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in molecules requiring a substituted anisole core for bioactivity or metabolic stability.
• Agrochemical Synthesis: Used in the manufacture of herbicides, fungicides, and insecticides, where the trifluoromethyl group often enhances lipophilicity and biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of advanced electronic materials, where its aromatic and halogenated structure contributes to desired electronic and mesomorphic properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution due to the activated chlorine atom.
• Dye & Pigment Intermediate: Utilized in the production of complex dyes and pigments, where it acts as a halogenated aromatic component.
• Research & Development: A valuable reagent for medicinal chemistry and material science research in academic and industrial laboratories.

Basic Information

Product Name	2-Chloro-5-(Trifluoromethyl)Anisole
CAS No.	402-08-4
Molecular Formula	C8H6ClF3O
Molecular Weight	210.58 g/mol
Synonyms	1-Chloro-2-methoxy-4-(trifluoromethyl)benzene; 2-Chloro-α,α,α-trifluoro-p-anisole; 2-Chloro-5-(trifluoromethyl)methoxybenzene; 4-Chloro-3-(trifluoromethyl)anisole; 2-Chloro-5-trifluoromethylanisole; Anisole, 2-chloro-5-(trifluoromethyl)-; Benzene, 1-chloro-2-methoxy-4-(trifluoromethyl)-
EINECS	206-933-5

Quality Control

Our 2-Chloro-5-(Trifluoromethyl)Anisole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is 2-25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.450 - 1.455
Density (20°C)	1.38 - 1.42 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.