Description

4-Chloro-3-(Trifluoromethyl)Anisole is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both chloro and trifluoromethyl substituents on an anisole ring, makes it a critical intermediate for creating complex molecules with tailored properties. This compound is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the trifluoromethyl group for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the chloro and trifluoromethyl groups contribute to biological activity.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for display technologies.
• Organic Electronic Materials: Intermediate for the development of specialty polymers and small molecules used in organic light-emitting diodes (OLEDs) and semiconductors.
• Dye and Pigment Manufacturing: Used in the synthesis of specialized fluorinated dyes and pigments.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing complex biaryl systems.

Basic Information

Product Name	4-Chloro-3-(Trifluoromethyl)Anisole
CAS No.	400-73-7
Molecular Formula	C8H6ClF3O
Molecular Weight	210.58 g/mol
Synonyms	1-Chloro-4-methoxy-2-(trifluoromethyl)benzene; 4-Chloro-3-(trifluoromethyl)phenyl methyl ether; 3-Trifluoromethyl-4-chloroanisole; 2-Trifluoromethyl-4-chloroanisole; 4-Chloro-alpha,alpha,α-trifluoro-m-anisole; Benzene, 1-chloro-4-methoxy-2-(trifluoromethyl)-; Anisole, 4-chloro-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-(Trifluoromethyl)Anisole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation via FT-IR and NMR, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.