Description

4,4,4-Trifluoro-3-Oxo-Butyric Acid is a versatile fluorinated β-keto acid building block of significant importance in advanced organic synthesis. Its unique structure, featuring both a reactive ketone and a carboxylic acid group, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to introduce the trifluoromethyl group—a key moiety known to enhance metabolic stability, lipophilicity, and bioavailability in active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing the trifluoromethyl group to improve drug efficacy and stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to enhanced biological activity and environmental persistence.
• Fluorinated Material Precursor: Serves as a starting material for synthesizing specialty polymers, liquid crystals, and other advanced materials requiring fluorinated segments.
• Organic Synthesis Reagent: Employed in various name reactions and coupling chemistries as a source of the -CO-CH2-COOH unit with fluorine substitution.
• Research & Development: A valuable tool in medicinal chemistry and material science R&D for exploring structure-activity relationships and developing new fluorinated compounds.

Basic Information

Product Name	4,4,4-Trifluoro-3-Oxo-Butyric Acid
CAS No.	400-36-2
Molecular Formula	C4H3F3O3
Molecular Weight	156.06 g/mol
Synonyms	4,4,4-Trifluoroacetoacetic Acid; 3-Oxo-4,4,4-trifluorobutanoic Acid; 4,4,4-Trifluoro-3-oxobutanoic Acid; TFAA; Trifluoroacetoacetic Acid; 3-Keto-4,4,4-trifluorobutyric Acid; 4,4,4-Trifluoro-β-ketobutyric Acid; 3-Oxotrifluorobutanoic Acid
EINECS	206-915-1

Quality Control

Our production of 4,4,4-Trifluoro-3-Oxo-Butyric Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR to verify identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support compliance with global regulatory frameworks, including REACH, and can tailor specifications to meet specific customer requirements for research or cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases, strong oxidizing agents, and strong reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.