Description

(E)-3-(Trifluoromethyl)Crotonic Acid is a high-value fluorinated organic building block characterized by its α,β-unsaturated carboxylic acid structure and a strategically positioned trifluoromethyl group. This compound matters for its unique ability to introduce both lipophilicity and metabolic stability into target molecules, making it a critical intermediate in advanced synthesis. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the CF₃ group enhances biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers with tailored surface properties and chemical resistance.
• Liquid Crystal & OLED Materials: Incorporated into the molecular structure of electronic display materials to modify dielectric constants and improve performance.
• Fluorine Chemistry Research: An essential reagent for academic and industrial research exploring new methodologies in organofluorine chemistry and catalysis.
• Peptide Mimetics & Bio-conjugation: The carboxylic acid functionality allows for amide bond formation, useful in creating peptide analogs or attaching fluorinated tags to biomolecules.

Basic Information

Product Name	(E)-3-(Trifluoromethyl)Crotonic Acid
CAS No.	400-28-2
Molecular Formula	C₅H₅F₃O₂
Molecular Weight	154.09 g/mol
Synonyms	(E)-3-(Trifluoromethyl)but-2-enoic acid; trans-3-(Trifluoromethyl)crotonic acid; 3-(Trifluoromethyl)-2-butenoic acid; (E)-3-(Trifluoromethyl)-2-butenoic acid; 2-Butenoic acid, 3-(trifluoromethyl)-, (2E)-; α,β-Didehydro-β-(trifluoromethyl)butyric acid; Trifluoromethylcrotonic Acid
EINECS	Contact for details

Quality Control

Our (E)-3-(Trifluoromethyl)Crotonic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	65 - 70 °C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.