Description

1,1,1,3,3,3-Hexafluoro-2-propanone semicarbazone is a high-value fluorinated organic intermediate, specifically a protected derivative of hexafluoroacetone. This compound is critical for its role as a stable synthon, enabling the controlled introduction of the hexafluoroisopropylidene group into complex molecules. It is primarily sought by research and development chemists in the pharmaceutical and advanced materials sectors for synthesizing novel compounds with enhanced thermal stability, chemical resistance, and unique biological activity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the hexafluoroisopropylidene moiety to modulate lipophilicity and metabolic stability.
• Advanced Polymer Synthesis: Used in the production of high-performance fluoropolymers and polyimides, imparting exceptional thermal stability, low dielectric constant, and chemical resistance for electronics and aerospace applications.
• Agrochemical Research: Serves as a precursor for developing novel fluorinated pesticides and herbicides, where the fluorine atoms can enhance bioavailability and environmental persistence.
• Liquid Crystal & OLED Materials: Incorporated into the core structures of fluorinated liquid crystals and organic light-emitting diode (OLED) materials to improve performance and durability.
• Specialty Chemical Synthesis: Employed in organic synthesis laboratories for creating complex fluorinated molecules for catalysis, sensing, and material science research.

Basic Information

Product Name	1,1,1,3,3,3-Hexafluoro-2-Propanone Semicarbazone
CAS No.	400-16-8
Molecular Formula	C4H3F6N3O
Molecular Weight	223.08 g/mol
Synonyms	Hexafluoroacetone Semicarbazone; 1,1,1,3,3,3-Hexafluoro-2-propanone, semicarbazone; 2-Propanone, 1,1,1,3,3,3-hexafluoro-, semicarbazone; HFA Semicarbazone; (Hexafluoropropan-2-ylidene)semicarbazide; 1-Aminourea, 2-(hexafluoroisopropylidene)hydrazide; NSC 5235
EINECS	Contact for details

Quality Control

Every batch of 1,1,1,3,3,3-Hexafluoro-2-propanone semicarbazone is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the precise requirements of your synthesis. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids, strong bases, and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.