Description

(R)-(+)-2,2'-Bis[Di(3,5-Xylyl)Phosphino]-6,6'-Dimethoxy-1,1'-Biphenyl,Min.97% is a high-purity, chiral bisphosphine ligand of the BINAP family, specifically designed for asymmetric catalysis. Its value lies in enabling highly enantioselective transformations, critical for producing single-isomer intermediates in fine chemical and pharmaceutical synthesis. This product is essential for R&D scientists and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemical control. The compound is supplied with a minimum purity of 97% to ensure consistent and reliable catalytic performance.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Critical for constructing chiral centers in active pharmaceutical ingredients (APIs), including those for cardiovascular, CNS, and antiviral drugs.
• Agrochemical Manufacturing: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Asymmetric C-C Bond Formation: Facilitates enantioselective cross-coupling and addition reactions for complex molecule assembly.
• Catalyst Screening & Process Development: A key tool in R&D for optimizing reaction conditions and scaling up chiral processes.
• Fine Chemical Production: Enables the manufacture of high-value chiral flavors, fragrances, and electronic chemicals.

Basic Information

Product Name	(R)-(+)-2,2'-Bis[Di(3,5-Xylyl)Phosphino]-6,6'-Dimethoxy-1,1'-Biphenyl, Min. 97%
CAS No.	394248-45-4
Molecular Formula	C58H58O2P2
Molecular Weight	849.02 g/mol
Synonyms	(R)-DTBM-SEGPHOS; (R)-(+)-2,2'-Bis(bis(3,5-dimethylphenyl)phosphino)-6,6'-dimethoxy-1,1'-biphenyl; (R)-DTBM-Segphos; (R)-5,5'-Bis[di(3,5-xylyl)phosphino]-4,4'-bi-1,3-benzodioxole; DTBM-SEGPHOS, (R)-; (R)-DTBM-SegPhos ligand; SEGPHOS derivative, DTBM-substituted; (R)-3,3',5,5'-Tetramethyl-4,4'-dimethoxy-2,2'-bis(di(3,5-dimethylphenyl)phosphino)-1,1'-biphenyl
EINECS	Contact for details

Quality Control

Every batch of our (R)-DTBM-SEGPHOS is subjected to rigorous analytical testing to ensure it meets the highest standards for chiral ligand applications. Quality is verified through multiple techniques including HPLC for chiral purity and assay, NMR for structural confirmation, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. Our quality management system supports compliance with cGMP and ISO standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (argon or nitrogen) at 2-8°C. The material is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Off-white to pale yellow powder or crystals
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	Min. 97.0%
Chiral Purity (HPLC)	Min. 99.0% ee
Solubility Test	Freely soluble in toluene, THF, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.