Description

3-Butynoicacid,2-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-2-Methyl-,(2S)-(9Ci) CAS NO 391678-36-7 is a high-purity, chiral building block featuring both a terminal alkyne and a protected amino acid moiety. This compound is essential for advanced organic synthesis, particularly in the development of novel pharmaceuticals and bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in peptide mimetics, bioconjugation, and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Mimetics & Conjugation: Used to incorporate non-natural amino acid structures and enable "click chemistry" via its alkyne functionality for bioconjugation.
• Medicinal Chemistry Research: Serves as a versatile building block in structure-activity relationship (SAR) studies and library synthesis for drug discovery.
• Chemical Biology Probes: Enables the labeling and study of biological systems through its reactive alkyne group.
• Agrochemical Synthesis: Potential intermediate in the development of advanced, chiral crop protection agents.
• Material Science: Can be used in the synthesis of specialized polymers and functional materials requiring precise molecular architecture.

Basic Information

Product Name	3-Butynoicacid,2-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-2-Methyl-,(2S)-(9Ci)
CAS No.	391678-36-7
Molecular Formula	C11H17NO4
Molecular Weight	227.26 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]-2-methyl-3-butynoic acid; Boc-D-α-methylpropargylglycine; Boc-Ampg-OH; N-Boc-2-amino-2-methyl-3-butynoic acid; (S)-2-((tert-Butoxycarbonyl)amino)-2-methylbut-3-ynoic acid; 2-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-methyl-3-butynoic acid, (2S)-; (S)-2-(Boc-amino)-2-methyl-3-butynoic acid
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to stringent quality protocols. Each batch is characterized and tested to ensure high chemical and enantiomeric purity, meeting the exacting standards required for pharmaceutical R&D. Comprehensive analysis includes HPLC, NMR, and optical rotation. Certificates of Analysis (COA) with full analytical data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.