Description

n-4-Fmoc-Aminocyclohexanone is a key protected amino ketone building block used in advanced organic synthesis. This compound is critical for the efficient construction of complex molecules, particularly in peptide and peptidomimetic research. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers for developing novel therapeutic candidates and high-value intermediates.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a crucial Fmoc-protected intermediate for introducing constrained cyclohexyl-based amino acid analogs into peptide chains.
• Peptidomimetic Drug Discovery: Enables the synthesis of conformationally restricted peptide mimics to enhance metabolic stability and receptor selectivity.
• Combinatorial Chemistry Libraries: Used as a versatile scaffold for generating diverse compound libraries for high-throughput screening.
• Linker Chemistry: Functions as a bifunctional handle in the synthesis of antibody-drug conjugates (ADCs) and other bioconjugates.
• Custom Synthesis of Fine Chemicals: Employed in the contract manufacturing of specialized intermediates for agrochemical and material science applications.
• Academic Research: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	n-4-Fmoc-Aminocyclohexanone
CAS No.	391248-11-6
Molecular Formula	C22H23NO3
Molecular Weight	349.42 g/mol
Synonyms	4-[(9H-Fluoren-9-ylmethoxy)carbonylamino]cyclohexanone; 4-(Fmoc-amino)cyclohexanone; 1-Fmoc-4-aminocyclohexanone; 4-(N-Fmoc)aminocyclohexanone; Fmoc-4-Amino-cyclohexanone; N-4-Fmoc-Aminocyclohexanone; 4-Fmoc-aminocyclohexanone; N-(9-Fluorenylmethoxycarbonyl)-4-aminocyclohexanone
EINECS	Contact for details

Quality Control

Our n-4-Fmoc-Aminocyclohexanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.