Description

Dispiro[2.0.2.1]Heptane-1-Methanol, 5,5-Difluoro-, (1S,3R,4S)- (9Ci) is a high-purity, stereochemically defined fluorinated building block of significant interest in advanced organic synthesis. Its unique spirocyclic core and strategically placed fluorine atoms make it a valuable precursor for constructing complex molecular architectures with tailored properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a sophisticated chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disease research.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, where the fluorine atoms can enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Acts as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Precursor: Employed in the research of specialty polymers and advanced materials where fluorinated moieties impart specific chemical resistance or surface properties.
• Chemical Biology Probe: Useful for incorporating fluorinated tags into biomolecules to study protein-ligand interactions or metabolic pathways.

Basic Information

Product Name	Dispiro[2.0.2.1]Heptane-1-Methanol, 5,5-Difluoro-, (1S,3R,4S)- (9Ci)
CAS No.	389873-51-2
Molecular Formula	C8H10F2O
Molecular Weight	160.16 g/mol
Synonyms	(1S,3R,4S)-5,5-Difluorodispiro[2.0.2.1]heptane-1-methanol; (1S,3R,4S)-5,5-Difluoro-1-(hydroxymethyl)dispiro[2.0.2.1]heptane; 5,5-Difluorodispiro[2.0.2.1]heptane-1-methanol, (1S,3R,4S)-; (1S,3R,4S)-5,5-Difluoro-dispiro[2.0.2.1]heptan-1-ylmethanol; Difluorinated Spirocyclic Methanol Derivative; CAS 389873-51-2
EINECS	Contact for details

Quality Control

Our production of Dispiro[2.0.2.1]Heptane-1-Methanol, 5,5-Difluoro-, (1S,3R,4S)- (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity, critical for sensitive R&D and scale-up processes. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing chiral purity, chemical assay, and impurity profiles. We implement controls aligned with ICH guidelines for impurities and utilize advanced analytical techniques including HPLC, GC, and NMR for verification.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is sensitive to strong alkalis and fluorides; ensure it is stored separately from such materials. Keep the container tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.