Description

(R)-1-[(R)-2-[2-(Diphenylphosphino)Phenyl]-Ferrocenyl]Ethyldicyclohexylphosphine is a high-value, chiral ferrocenyl phosphine ligand, a cornerstone in modern asymmetric catalysis. Its core value lies in enabling highly enantioselective transformations, crucial for producing single-isomer pharmaceutical intermediates and fine chemicals with superior purity and yield. This ligand is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require robust and selective catalysts for hydrogenation, cross-coupling, and other pivotal synthetic steps.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, critical for synthesizing chiral active pharmaceutical ingredients (APIs).
• Cross-Coupling Reactions: Facilitates asymmetric C-C and C-X bond-forming reactions, such as Suzuki-Miyaura and Buchwald-Hartwig couplings, with high enantiocontrol.
• Pharmaceutical Intermediate Synthesis: Used in the development and scale-up of chiral drugs, including β-blockers, antidepressants, and antiviral agents.
• Agrochemical Manufacturing: Enables the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A vital tool for methodology development in academic laboratories and process chemistry optimization in industrial settings.
• Catalyst Screening Libraries: A key component in high-throughput screening kits for identifying optimal catalytic systems for challenging transformations.

Basic Information

Product Name	(R)-1-[(R)-2-[2-(Diphenylphosphino)Phenyl]-Ferrocenyl]Ethyldicyclohexylphosphine
CAS No.	388079-60-5
Molecular Formula	C46H48FeP2
Molecular Weight	718.66 g/mol
Synonyms	(R,R)-JOSIPHOS; (R)-1-[(S)-2-(Diphenylphosphino)ferrocenyl]ethyldicyclohexylphosphine; (R)-1-[(S)-2-[2-(Diphenylphosphino)phenyl]ferrocenyl]ethyldicyclohexylphosphine; JOSIPHOS SL-J009-1; (R,R)-JOSIPHOS ligand; (1R)-1-[(SP)-2-[2-(Diphenylphosphanyl)phenyl]ferrocenyl]ethyldi(cyclohexyl)phosphane; Walphos SL-J009-1
EINECS	Contact for details

Quality Control

Every batch of our chiral phosphine ligands is manufactured and tested under strict quality control protocols to ensure exceptional purity and enantiomeric excess (ee) for reliable catalytic performance. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as assay, chiral purity (by HPLC or NMR), and residual solvent content. Our production adheres to cGMP principles where applicable, supporting our commitment to supply chain reliability and regulatory compliance for advanced synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	Orange to red powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (ee)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.