Description

Erythro-n-Boc-L-3,5-Difluorophenylalanine Epoxide is a high-purity, chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex bioactive molecules, particularly in medicinal chemistry and drug discovery programs. It is primarily utilized by research institutions and pharmaceutical manufacturers developing novel therapeutics, including protease inhibitors and other targeted agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for targeted therapies.
• Protease Inhibitor Synthesis: Serves as a crucial precursor in the construction of peptide-mimetic compounds designed to inhibit specific enzymatic pathways.
• Medicinal Chemistry & Drug Discovery: Used in lead optimization and structure-activity relationship (SAR) studies to introduce the difluorophenylalanine moiety with defined stereochemistry.
• Peptidomimetic Research: Enables the incorporation of fluorinated, non-natural amino acid analogs into peptide backbones to enhance metabolic stability and binding affinity.
• Chemical Biology Tool Development: Employed in the creation of specialized probes and labeled compounds for studying biological mechanisms.
• Process Chemistry & Scale-up: Suitable for use in developing robust and scalable synthetic routes from laboratory to pilot plant scale.

Basic Information

Product Name	Erythro-n-Boc-L-3,5-Difluorophenylalanine Epoxide
CAS No.	388071-27-0
Molecular Formula	C₁₄H₁₅F₂NO₅
Molecular Weight	315.27 g/mol
Synonyms	(2S,3S)-3-[(tert-Butoxycarbonyl)amino]-3-(3,5-difluorophenyl)oxirane-2-carboxylic Acid; (2S,3S)-N-Boc-3-(3,5-Difluorophenyl)glycidamide; Erythro-N-Boc-3,5-Difluoro-L-phenylalanine Epoxide; Boc-L-3,5-Difluorophenylalanine Epoxide (erythro); (2S,3S)-1-(tert-Butoxycarbonylamino)-1-(3,5-difluorophenyl)-2,3-epoxypropane; A Chiral Difluorinated Phenylalanine Epoxide Derivative
EINECS	Contact for details

Quality Control

Our Erythro-n-Boc-L-3,5-Difluorophenylalanine Epoxide is manufactured under controlled conditions to ensure high chemical and chiral purity, suitable for demanding research and development applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles. We adhere to strict internal quality standards to guarantee batch-to-batch consistency and reliability for your synthetic workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% (Erythro isomer)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.