Description

(R)-(-)-1-[(R)-2-(2'-Diphenylphosphinophenyl)Ferrocenyl]Ethyldi(Bis-3,5-Cf3-Ph2)P is a highly specialized, chiral ferrocenyl phosphine ligand, a cornerstone in modern asymmetric catalysis. Its value lies in its ability to impart exceptional enantioselectivity and catalytic activity in a range of transition-metal-catalyzed transformations, enabling the synthesis of complex, single-enantiomer molecules. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require high-performance, tunable ligands for developing efficient synthetic routes to chiral intermediates and active ingredients.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, critical for producing chiral amines, alcohols, and amino acid derivatives.
• Asymmetric C-C Bond Formation: Employed in cross-coupling reactions (e.g., Suzuki-Miyaura, Heck) and allylic substitution reactions to construct chiral carbon frameworks with high fidelity.
• Pharmaceutical Intermediate Synthesis: Key catalyst component in the production of enantiomerically pure active pharmaceutical ingredients (APIs) for central nervous system, cardiovascular, and oncological therapeutics.
• Agrochemical Active Ingredient Manufacture: Used to create chiral herbicides, fungicides, and pesticides where the biological activity is often specific to one enantiomer.
• Fine Chemical and Flavor/Fragrance Synthesis: Facilitates the production of high-value, single-isomer specialty chemicals, flavors, and aroma compounds.
• Academic and Industrial Catalyst Research: Serves as a benchmark and starting point for developing new chiral ligand libraries and catalytic systems.

Basic Information

Item	Details
Product Name	(R)-(-)-1-[(R)-2-(2'-Diphenylphosphinophenyl)Ferrocenyl]Ethyldi(Bis-3,5-Cf3-Ph2)P
CAS No.	387868-06-6
Molecular Formula	C61H38F12FeP3
Molecular Weight	1108.73 g/mol
Synonyms	(R)-JOSIPHOS SL-J009-1; (R)-1-[(S)-2-(2'-Diphenylphosphino)ferrocenyl]ethyldi(3,5-bis(trifluoromethyl)phenyl)phosphine; (R)-1-[(S)-2-(Diphenylphosphino)ferrocenyl]ethyldi(3,5-bis(trifluoromethyl)phenyl)phosphine; Josiphos SL-J009-1; J009-1 Ligand; (R)-SL-J009-1; Chiral Ferrocenyl Phosphine Ligand J009-1; (R)-1-[(R)-2-(Diphenylphosphino)ferrocenyl]ethyldi(3,5-bis(trifluoromethyl)phenyl)phosphine
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and controlled under strict inert atmosphere conditions to prevent oxidation and degradation. We employ advanced analytical techniques including HPLC, 31P/1H/19F/13C NMR, and elemental analysis (CHN) to verify identity, enantiomeric purity, and chemical purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry place. This compound is moisture-sensitive (hygroscopic) and easily oxidized; prolonged exposure to air, moisture, or ambient temperature should be avoided to maintain optimal catalytic performance and shelf life.

Specification

Item	Specification
Appearance	Orange to red powder or crystals
Identification (IR)	Conforms to structure
Identification (31P NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Moisture Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.