Description

Sodium (3-Sulfonatopropyl) Methanethiosulfonate is a versatile, water-soluble sulfonate derivative of methanethiosulfonate (MTS), a key class of reagents for site-directed chemical modification of proteins and other biomolecules. Its primary value lies in its ability to introduce a permanent, negatively charged sulfonate group via a disulfide bond, making it essential for studying protein structure, function, and stability. This compound is particularly valuable for researchers and manufacturers in bioconjugation, structural biology, and pharmaceutical development who require reliable, high-purity reagents for precise molecular engineering.

Application

• Site-Directed Protein Labeling and Modification: Used to introduce a stable, charged sulfonate group onto specific cysteine residues in proteins for functional studies.
• Bioconjugation and Linker Chemistry: Serves as a key intermediate or reagent for creating stable, charged linkages between biomolecules (e.g., antibodies, enzymes) and other entities like drugs, dyes, or surfaces.
• Structural Biology and Cysteine Mapping: Employed to probe protein structure, folding, and dynamics by selectively modifying solvent-accessible cysteine thiol groups.
• Pharmaceutical Research & ADC Development: Used in the research and development of antibody-drug conjugates (ADCs) and other targeted therapeutics where controlled, site-specific conjugation is critical.
• Surface Functionalization: Applied to modify gold surfaces or nanoparticles with a charged, self-assembled monolayer (SAM) for biosensor and diagnostic applications.
• Cross-linking and Stabilization: Can be used to introduce intramolecular or intermolecular cross-links in proteins to enhance stability or lock specific conformations.

Basic Information

Product Name	Sodium (3-Sulfonatopropyl) Methanethiosulfonate
CAS No.	385398-83-4
Molecular Formula	C4H9NaO5S3
Molecular Weight	256.29 g/mol
Synonyms	MTSES Sodium Salt; Sodium 3-(Methanethiosulfonato)propanesulfonate; (3-Sulfonatopropyl) Methanethiosulfonate Sodium Salt; MTSES; Sodium MTSES; 2-Sulfonatoethyl Methanethiosulfonate (common misnomer); SP-MTS; Contact for additional trade names and abbreviations.
EINECS	Contact for details

Quality Control

Our Sodium (3-Sulfonatopropyl) Methanethiosulfonate is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as purity (HPLC), identity (NMR/IR), and moisture content. We adhere to relevant GMP and ISO 9001 principles in our manufacturing and quality assurance processes to support our global customer base in life sciences and pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Solubility (Water)	Clear, colorless solution

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.