Description

2-(Dicyclohexylphosphino)-1,1-diphenyl-1-propene, also known as dicyclohexyl(1-methyl-2,2-diphenylvinyl)phosphine, is a specialized, bulky phosphine ligand critical for enabling challenging catalytic transformations. Its sterically demanding and electron-rich structure makes it an indispensable tool for researchers and process chemists developing novel synthetic pathways. This high-value ligand is primarily utilized in the fine chemical, pharmaceutical, and advanced materials sectors for cross-coupling reactions and the synthesis of complex organic molecules.

Application

• Cross-Coupling Catalysis: As a key ligand in palladium-catalyzed reactions such as Suzuki-Miyaura, Buchwald-Hartwig amination, and Negishi couplings for C-C and C-N bond formation.
• Pharmaceutical Intermediate Synthesis: Enabling the construction of complex, sterically hindered molecular architectures found in active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Serving as a chiral ligand precursor or modifier in the development of enantioselective catalytic processes.
• Material Science Research: Facilitating the synthesis of novel organic electronic materials, polymers, and ligands for metal-organic frameworks (MOFs).
• Academic & Industrial R&D: A valuable reagent for methodology development and exploring new reaction spaces in organometallic chemistry.
• Scale-up Process Optimization: Improving catalyst efficiency, turnover number (TON), and selectivity in pilot and commercial-scale chemical production.

Basic Information

Item	Details
Product Name	2-(Dicyclohexylphosphino)-1,1-Diphenyl-1-Propene
CAS No.	384842-24-4
Molecular Formula	C28H37P
Molecular Weight	404.57 g/mol
Synonyms	Dicyclohexyl(1-Methyl-2,2-Diphenylvinyl)Phosphine; 2-(Dicyclohexylphosphino)-1,1-diphenylprop-1-ene; (1-Methyl-2,2-diphenylvinyl)dicyclohexylphosphine; Dicyclohexyl(1-methyl-2,2-diphenylethenyl)phosphine; Bulky Dicyclohexylphosphine Ligand; DCPDP
EINECS	Contact for details

Quality Control

Every batch of our 2-(Dicyclohexylphosphino)-1,1-diphenyl-1-propene is manufactured and tested under stringent quality management systems to ensure exceptional purity and performance consistency, critical for sensitive catalytic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (by NMR and HPLC), identity confirmation, and moisture content. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to oxidation, the container should only be opened in an inert environment and resealed immediately after use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (NMR)	≥ 97.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.