Description

1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Biotinyl) (Sodium Salt) is a high-purity, synthetic phospholipid derivative covalently linked to biotin, widely recognized as a critical reagent in advanced life science research and diagnostic development. Its core value lies in enabling the specific, high-affinity labeling and isolation of biomembranes and liposomes through the strong biotin-streptavidin interaction. This compound is essential for researchers and manufacturers in pharmaceutical R&D, targeted drug delivery systems, and in vitro diagnostic (IVD) kit production, where precise membrane targeting and conjugation are paramount.

Application

• Liposome Surface Functionalization: For creating targeted drug delivery vehicles (e.g., for cancer therapeutics) by anchoring biotin to the liposomal surface for subsequent streptavidin-mediated coupling to targeting ligands like antibodies.
• Membrane Protein Studies: Used to incorporate biotin tags into artificial lipid bilayers or cell membranes to isolate, purify, or visualize membrane-associated proteins and complexes.
• Biosensor & Diagnostic Assay Development: Serves as a key component in surface plasmon resonance (SPR), ELISA, and lateral flow assays where a stable, oriented lipid layer is required to capture analytes.
• Model Membrane Research: Employed in biophysical studies to create supported lipid bilayers (SLBs) or giant unilamellar vesicles (GUVs) with defined surface chemistry for interaction studies.
• Cell Sorting & Separation: Facilitates the isolation of specific cell populations by incorporating the biotinylated lipid into cell membranes for capture with streptavidin-coated beads or columns.
• Nanoparticle Conjugation: Enables the functionalization of lipid nanoparticles (LNPs) and other nanocarriers with biotin for modular attachment of various biomolecules.

Basic Information

Product Name	1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Biotinyl) (Sodium Salt)
CAS No.	384835-54-5
Molecular Formula	C73H138N4NaO11P
Molecular Weight	1341.88 g/mol
Synonyms	Biotinylated DPPE; Biotin-DPPE; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-(biotinyl); DPPE-Biotin; Biotinyl Cap PE; 16:0 Biotinyl Cap PE; Biotin PE; Biotin Phosphatidylethanolamine; N-((6-(Biotinoyl)amino)hexanoyl)-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine Sodium Salt
EINECS	Contact for details

Quality Control

Our 1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Biotinyl) (Sodium Salt) is manufactured under strict quality systems to ensure batch-to-batch consistency and high performance in sensitive applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, MS for identity confirmation, and NMR for structural verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. Production adheres to cGMP guidelines where applicable, supporting its use in pre-clinical and diagnostic development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated under an inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC-MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay (Phosphorus Content)	≥ 85% (of theoretical)
Solubility	Soluble in chloroform, DMSO, ethanol; forms micelles in water
Residual Solvents (GC)	Meets ICH guidelines
Biotin Content	≥ 0.9 mol biotin / mol phospholipid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.