Description

tert-Butyl 2-Bromo-4-Nitrophenylcarbamate is a specialized organic building block of significant importance in advanced chemical synthesis. This compound serves as a key intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of active pharmaceutical ingredients (APIs) and other high-value compounds.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel drug candidates, especially those containing substituted aniline or benzamide motifs.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides where the bromo and nitro functional groups allow for further derivatization.
• Fine Chemical Production: Serves as a versatile building block for creating complex dyes, pigments, and specialty polymers requiring specific aromatic substitution patterns.
• Cross-Coupling Reactions: The bromo substituent makes it a suitable substrate for palladium-catalyzed cross-coupling reactions, such as Suzuki or Buchwald-Hartwig amination, to form biaryl or C-N bonds.
• Protecting Group Chemistry: The tert-butyloxycarbonyl (Boc) group can act as a protecting group for amines in complex synthetic sequences, with the other functional groups allowing for orthogonal deprotection or modification.
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and other advanced materials where electron-withdrawing nitro groups and aromatic bromides are beneficial.

Basic Information

Product Name	tert-Butyl 2-Bromo-4-Nitrophenylcarbamate
CAS No.	384793-20-8
Molecular Formula	C11H13BrN2O4
Molecular Weight	317.14 g/mol
Synonyms	2-Bromo-4-nitroaniline, N-Boc derivative; Carbamic acid, N-(2-bromo-4-nitrophenyl)-, 1,1-dimethylethyl ester; tert-Butyl N-(2-bromo-4-nitrophenyl)carbamate; N-Boc-2-bromo-4-nitroaniline; Boc-2-Br-4-NO2-aniline; 1-(tert-Butoxycarbonylamino)-2-bromo-4-nitrobenzene; (2-Bromo-4-nitrophenyl)carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Bromo-4-Nitrophenylcarbamate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and may require storage under an inert atmosphere for long-term stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.