Description

3,6,9,12,15-Pentaoxaheptadecane-1,17-Diyl Bis-Methanethiosulfonate is a specialized bifunctional crosslinking agent featuring a hydrophilic polyethylene glycol (PEG) spacer terminated with reactive methanethiosulfonate groups. This compound is engineered to enable the controlled and reversible formation of disulfide bonds, a critical feature for applications in bioconjugation and materials science. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for protein modification, surface functionalization, and the development of smart hydrogels and drug delivery systems.

Application

• Protein and Antibody Conjugation: Used as a heterobifunctional crosslinker for site-specific labeling of proteins, antibodies, and peptides, enabling the attachment of fluorophores, drugs, or other biomolecules via a cleavable disulfide linkage.
• Surface Modification and Immobilization: Facilitates the functionalization of gold surfaces, nanoparticles, and other materials with biomolecules for biosensor development and diagnostic assay platforms.
• Polymer and Hydrogel Synthesis: Serves as a crosslinking agent in the synthesis of stimuli-responsive (e.g., redox-sensitive) hydrogels and polymers for controlled drug release applications.
• Bioconjugation Reagent Kits: A key component in commercial and in-house bioconjugation kits designed for creating stable yet reversible linkages in complex biological systems.
• Liposome and Micelle Functionalization: Employed to attach targeting ligands or stealth polymers (like PEG) to nanocarrier systems via a disulfide bond for targeted and triggered drug delivery.
• Stem Cell and Tissue Engineering: Used to modify extracellular matrix components or scaffold surfaces to create reversible cell-adhesive environments.

Basic Information

Product Name	3,6,9,12,15-Pentaoxaheptadecane-1,17-Diyl Bis-Methanethiosulfonate
CAS No.	384342-61-4
Molecular Formula	C13H26O11S4
Molecular Weight	510.60 g/mol
Synonyms	Bis-MTS-PEG5; PEG5 Bis-Methanethiosulfonate; 1,17-Bis(methanethiosulfonyl)-3,6,9,12,15-pentaoxaheptadecane; MTS-PEG5-MTS; Heterobifunctional PEG Crosslinker, MTS terminated; DTSSP-PEG5 Analog; (Ethylene glycol)5 bis(2-methanethiosulfonate) ether
EINECS	Contact for details

Quality Control

Our 3,6,9,12,15-Pentaoxaheptadecane-1,17-Diyl Bis-Methanethiosulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure it meets the high standards required for research and bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.