Description

Abacavir 5'-Glucuronide is a major, pharmacologically inactive metabolite of the antiretroviral drug Abacavir. This reference standard is critical for analytical research and development, enabling precise quantification and metabolic profiling. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and quality control departments for method validation, bioanalytical studies, and ensuring drug safety and efficacy.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the identification and quantification of Abacavir metabolites in biological matrices.
• Bioanalytical Method Development & Validation: Essential for developing and validating HPLC, LC-MS, and LC-MS/MS methods in pharmacokinetic (PK) and toxicokinetic (TK) studies.
• Drug Metabolism and Pharmacokinetics (DMPK) Research: Used to study the glucuronidation pathway, metabolic stability, and clearance mechanisms of Abacavir.
• Quality Control & Impurity Profiling: Acts as a known impurity or metabolite standard to monitor product quality and stability in active pharmaceutical ingredient (API) batches.
• Clinical Research: Supports studies investigating patient metabolism, drug-drug interactions, and personalized medicine approaches for HIV treatment.
• Regulatory Submissions: Provides essential data for regulatory filings (e.g., FDA, EMA) requiring comprehensive metabolite characterization.

Basic Information

Product Name	Abacavir 5'-Glucuronide
CAS No.	384329-76-4
Molecular Formula	C20H27N5O9
Molecular Weight	481.46 g/mol
Synonyms	Abacavir Glucuronide; Abacavir 5'-O-β-D-Glucuronide; (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol 5'-O-β-D-Glucopyranosiduronic Acid; Abacavir 5'-β-D-Glucuronide; Abacavir-5'-glucuronide; Abacavir D5 Glucuronide (deuterated analog); Ziagen Glucuronide (related to trade name)
EINECS	Contact for details

Quality Control

Our Abacavir 5'-Glucuronide is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with lot-specific data to support your research and regulatory needs. The product is suitable for use as a high-purity reference standard in pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.