Description

o-Desmethyl Tramadol β-D-Glucuronide is a major, pharmacologically relevant Phase II metabolite of the analgesic tramadol. This reference standard is critical for analytical and research applications requiring precise quantification and identification. It is primarily utilized by pharmaceutical R&D laboratories, forensic toxicology units, and contract research organizations (CROs) for method development, validation, and quality control in bioanalytical studies.

Application

• Pharmaceutical Reference Standard: Serves as a certified primary standard for the quantitative analysis of tramadol and its metabolites in biological matrices (e.g., plasma, urine).
• Bioanalytical Method Development: Essential for developing and validating sensitive HPLC-MS/MS or LC-UV methods for pharmacokinetic and toxicokinetic studies.
• Forensic Toxicology: Used as a calibrator or control in assays to confirm tramadol use, aiding in post-mortem analysis and workplace drug testing.
• Metabolite Research: Enables studies on the metabolic pathways, activity, and elimination profile of tramadol in preclinical and clinical research.
• Quality Control in Manufacturing: Supports impurity profiling and stability testing of tramadol drug substances and products.
• Clinical Trial Support: Provides a benchmark for measuring metabolite concentrations in patient samples during clinical trials.

Basic Information

Product Name	o-Desmethyl Tramadol β-D-Glucuronide
CAS No.	383891-39-2
Molecular Formula	C21H31NO8
Molecular Weight	425.47 g/mol
Synonyms	O-Desmethyltramadol Glucuronide; O-DSMT Glucuronide; M1 Glucuronide; Tramadol Metabolite M1 Glucuronide; 2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol Glucuronide; O-Desmethyl Tramadol β-D-Glucopyranosiduronic Acid; N-Desmethyl-O-desmethyl Tramadol Glucuronide (common misnomer)
EINECS	Contact for details

Quality Control

Every batch of o-Desmethyl Tramadol β-D-Glucuronide is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the stringent requirements for reference materials. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting results from HPLC, MS, NMR, and other relevant tests.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.