Description

2-Ethynyl-1,3-Difluoro-Benzene is a high-value, multi-functional aromatic building block characterized by its ethynyl and fluorine substituents. This compound is essential for advanced organic synthesis, enabling the construction of complex molecular architectures through cross-coupling and cycloaddition reactions. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and fungicides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Ligand and Catalyst Development: Employed to construct sophisticated ligands for transition metal catalysis and organocatalysis.
• Fluorine Chemistry Research: A valuable substrate for studying new fluorination methodologies and the effects of fluorine substitution.
• Chemical Library Synthesis: Used in combinatorial and parallel synthesis for high-throughput screening in drug discovery programs.

Basic Information

Product Name	2-Ethynyl-1,3-Difluoro-Benzene
CAS No.	381723-16-6
Molecular Formula	C8H4F2
Molecular Weight	138.12 g/mol
Synonyms	1,3-Difluoro-2-ethynylbenzene; 2-Ethynyl-1,3-difluorobenzene; 1,3-Difluoro-2-ethylnylbenzene; 2-Ethynyl-m-difluorobenzene; m-Difluoro-2-ethynylbenzene; 2-Ethynyl-1,3-difluoro-benzene; Benzene, 2-ethynyl-1,3-difluoro-; (2,6-Difluorophenyl)acetylene
EINECS	Contact for details

Quality Control

Our 2-Ethynyl-1,3-Difluoro-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.