Description

n-[(2,3,5,6-Tetramethylphenyl)Sulfonyl]Phenylalanine is a specialized, high-purity synthetic intermediate characterized by its unique sulfonamide-linked aromatic structure. This compound matters for its role as a critical building block in advanced pharmaceutical research and fine chemical synthesis, where precise molecular architecture is paramount. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for constructing novel active compounds and exploring new synthetic pathways.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting enzyme inhibition or requiring specific chiral centers.
• Peptidomimetic Research: Serves as a non-natural amino acid derivative for developing peptide analogs with enhanced metabolic stability and bioavailability.
• Protease Inhibitor Development: Utilized in constructing scaffolds for inhibitors of various proteases due to its phenylalanine and sulfonyl components.
• Chemical Biology Probes: Acts as a building block for creating activity-based probes and labeled compounds for studying biological pathways.
• Agrochemical Synthesis: Intermediate in the development of new generation herbicides or plant growth regulators with specific activity profiles.
• Material Science: Potential monomer or additive for specialized polymers where the tetramethylphenyl group imparts specific steric or electronic properties.

Basic Information

Product Name	n-[(2,3,5,6-Tetramethylphenyl)Sulfonyl]Phenylalanine
CAS No.	381687-95-2
Molecular Formula	C20H25NO4S
Molecular Weight	375.48 g/mol
Synonyms	N-(2,3,5,6-Tetramethylphenylsulfonyl)-L-phenylalanine; (2S)-2-[[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino]-3-phenylpropanoic acid; L-Phenylalanine, N-[(2,3,5,6-tetramethylphenyl)sulfonyl]-; Tetramethylbenzenesulfonyl phenylalanine; TMBS-Phe; N-TMBS-L-phenylalanine; N-(Tetramethylphenylsulfonyl)phenylalanine
EINECS	Contact for details

Quality Control

Every batch of n-[(2,3,5,6-Tetramethylphenyl)Sulfonyl]Phenylalanine is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.