Description

[(Pf)Phe4]Nociceptin(1-13)Nh2 is a synthetic, fluorinated analog of the endogenous neuropeptide nociceptin (orphanin FQ), specifically designed for enhanced metabolic stability and receptor binding affinity. This modified peptide is a critical research tool for investigating the Nociceptin Opioid Peptide (NOP) receptor system, which plays a significant role in modulating pain, anxiety, and reward pathways. It is primarily utilized by pharmaceutical researchers, neuroscientists, and academic institutions engaged in preclinical studies for central nervous system (CNS) disorders and analgesic development.

Application

• Neuroscience Research: A key ligand for studying the pharmacology and signaling of the NOP receptor in vitro and in vivo.
• Pain Mechanism Studies: Investigation of novel, non-opioid pathways for pain modulation and the development of next-generation analgesics.
• Drug Discovery Screening: Used in high-throughput screening (HTS) assays to identify and characterize new NOP receptor agonists or antagonists.
• Behavioral Pharmacology: Research into the role of the nociceptin system in anxiety, depression, stress response, and addiction behaviors.
• Biochemical Assay Development: Serves as a standard or reference compound in receptor binding and functional assays (e.g., cAMP, GTPγS).
• Metabolic Stability Studies: The fluorinated modification makes it a model compound for studying peptide stability and pharmacokinetics.

Basic Information

Product Name	[(Pf)Phe4]Nociceptin(1-13)Nh2
CAS No.	380620-88-2
Molecular Formula	C81H105F4N19O16
Molecular Weight	1684.8 g/mol
Synonyms	[(pF)Phe4]Nociceptin(1-13)amide; Nociceptin (1-13), 4-[4-fluorophenyl]alanine-; Orphanin FQ (1-13) amide, [Phe4(p-F)]-; [Phe4(p-F)]-Orphanin FQ (1-13)NH2; [p-F-Phe4]-Nociceptin(1-13)NH2; NOP receptor ligand analog; Fluorinated nociceptin fragment; Research peptide 380620-88-2
EINECS	Contact for details

Quality Control

Our research-grade peptides are manufactured under strict quality management systems. Each batch of [(Pf)Phe4]Nociceptin(1-13)Nh2 undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing batch-specific results are provided to ensure traceability and reproducibility for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.