Description

Human IL-8 is a high-purity, biologically active chemokine critical for research and development in immunology and inflammation studies. This product, Human IL-8 CAS NO 378763-92-9, is essential for investigating neutrophil activation, chemotaxis, and the pathophysiology of chronic inflammatory diseases. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic manufacturers requiring a reliable and consistent cytokine source for assay development and biological studies.

Application

• Biomedical Research: Fundamental studies on inflammatory pathways, leukocyte migration, and immune cell signaling.
• Drug Discovery & Development: Target validation and screening for anti-inflammatory therapeutics in conditions like rheumatoid arthritis, COPD, and psoriasis.
• Diagnostic Assay Development: Used as a standard or calibrator in ELISA, Luminex, and other immunoassays to quantify IL-8 levels in clinical samples.
• Cell Culture & In Vitro Models: Stimulation of neutrophils and other immune cells in controlled laboratory environments to study cellular responses.
• Biomarker Research: Investigation of IL-8 as a prognostic or diagnostic marker in various cancers and inflammatory diseases.
• Vaccine Adjuvant Research: Exploration of its role in modulating immune responses in next-generation vaccine formulations.

Basic Information

Product Name	Human IL-8
CAS No.	378763-92-9
Molecular Formula	C432H688N120O126S10
Molecular Weight	~8.8 kDa (monomer)
Synonyms	Interleukin-8; IL-8; CXCL8; Chemokine (C-X-C motif) ligand 8; Monocyte-derived neutrophil chemotactic factor; Neutrophil-activating peptide 1; NAP-1; Granulocyte chemotactic protein 1; GCP-1; Protein 3-10C; T-cell chemotactic factor; LECT; LUCT; LYNAP; MDNCF; SCYB8
EINECS	Contact for details

Quality Control

Our Human IL-8 is produced under stringent conditions to ensure batch-to-batch consistency and biological activity. Each lot undergoes rigorous quality testing, including purity analysis by HPLC, confirmation of biological activity in standardized cell-based assays, and endotoxin level testing. Certificates of Analysis (COA) detailing purity, potency, and specification results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C to -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the vial is at room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Purity (SDS-PAGE)	≥ 95%
Purity (HPLC)	≥ 98%
Biological Activity	Determined by cell proliferation/chemotaxis assay
Endotoxin Level	< 1.0 EU/μg
Identification (Mass Spec)	Consistent with theoretical molecular weight
Solubility	Soluble in water or PBS

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.