Description

3-(2,4,6-Trifluoro-Phenyl)-Propionic Acid Ethyl Ester is a high-purity fluorinated aromatic ester, a critical building block in advanced organic synthesis. Its unique trifluoromethylphenyl moiety offers enhanced lipophilicity and metabolic stability, making it invaluable for creating novel compounds with specific properties. This intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorine atoms contribute to biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, contributing to improved electronic properties.
• Advanced Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, enhancing their chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Building Block: A versatile reagent for coupling reactions (e.g., Suzuki, Heck) and esterification/transesterification processes in complex molecule assembly.
• Chemical Research & Development: Essential for medicinal chemistry and material science research exploring structure-activity relationships (SAR) of fluorinated compounds.

Basic Information

Product Name	3-(2,4,6-Trifluoro-Phenyl)-Propionic Acid Ethyl Ester
CAS No.	377084-09-8
Molecular Formula	C11H9F3O2
Molecular Weight	230.18 g/mol
Synonyms	Ethyl 3-(2,4,6-Trifluorophenyl)propanoate; 2,4,6-Trifluorobenzene propanoic acid ethyl ester; 3-(2,4,6-Trifluorophenyl)propionic Acid Ethyl Ester; Ethyl 3-(2,4,6-Trifluorophenyl)propionate; Propanoic acid, 3-(2,4,6-trifluorophenyl)-, ethyl ester; 377084-09-8; Ethyl (2,4,6-Trifluorophenyl)propanoate
EINECS	Contact for details

Quality Control

Our 3-(2,4,6-Trifluoro-Phenyl)-Propionic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.