Description

Ceftobiprole Medocaril CAS NO 376653-43-9 is a water-soluble prodrug of the advanced-generation cephalosporin antibiotic, ceftobiprole. This compound is of critical importance as the active pharmaceutical ingredient (API) in the development of potent anti-MRSA (Methicillin-resistant *Staphylococcus aureus*) therapeutics. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development, formulation, and production of next-generation injectable antibiotics targeting multidrug-resistant Gram-positive and Gram-negative bacterial infections.

Application

• Pharmaceutical API: Serves as the key active ingredient in the commercial production of anti-infective injectable formulations.
• Antibacterial Drug Development: Used in R&D for creating new drugs effective against resistant pathogens like MRSA and *Pseudomonas aeruginosa*.
• Clinical Research Material: Employed as a reference standard and raw material in pharmacokinetic, stability, and efficacy studies.
• Hospital-Acquired Infection Treatment: Basis for medications targeting complicated skin and skin structure infections (cSSSI) and pneumonia.
• Veterinary Pharmaceutical Synthesis: Potential use in developing advanced antibacterial treatments for veterinary medicine.

Basic Information

Product Name	Ceftobiprole Medocaril
CAS No.	376653-43-9
Molecular Formula	C₂₆H₃₁N₉O₁₀S₂
Molecular Weight	693.73 g/mol
Synonyms	Ceftobiprole Medocaril Sodium; Ceftobiprole Medocaril (Sterile); BAL-5788; RO-65-5788; (6R,7R)-7-[(2Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetamido]-3-[(3R,4R)-4-{[(3-carboxypropanoyl)oxy]methyl}-3-(phosphonooxy)pyridin-1-ium-1-yl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; Ceftobiprole Pivoxil Hydrochloride (common misnomer); Zevtera/Zeftera API
EINECS	Contact for details

Quality Control

Our Ceftobiprole Medocaril is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use. Specifications typically align with pharmacopeial requirements for related cephalosporin APIs. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) or as specified on the label. The product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccated environment to maintain stability and potency. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Bacterial Endotoxins	< 0.10 EU/mg
Sterility (for sterile grade)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.