Description

Fmoc-2,5,7-Tri-2,5,7-Tris-tert-Butyl-L-Tryptophan is a sophisticated, orthogonally protected derivative of the essential amino acid L-tryptophan, designed for advanced peptide synthesis. This compound is engineered to provide exceptional steric protection for the indole side chain, preventing unwanted side reactions during complex solid-phase peptide assembly. It is a critical building block for researchers and manufacturers in pharmaceutical development, particularly for creating peptides with enhanced stability and specific biological activity.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, enabling the synthesis of complex peptides and small proteins.
• Pharmaceutical Research & Development: Used in the discovery and production of peptide-based therapeutics, including hormone analogs, antimicrobial peptides, and targeted drug conjugates.
• Bioconjugation & Chemical Biology: Serves as a precursor for introducing the tryptophan moiety into biomolecules for labeling, probing protein-protein interactions, or modifying protein function.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify novel bioactive peptide leads.
• Academic Research: Essential for studies in peptide chemistry, structural biology, and the investigation of protein folding and stability.

Basic Information

Product Name	Fmoc-2,5,7-Tri-2,5,7-Tris-tert-Butyl-L-Tryptophan
CAS No.	376592-37-9
Molecular Formula	C46H60N2O4
Molecular Weight	704.99 g/mol
Synonyms	Fmoc-L-Trp(2,5,7-Tri-t-Bu)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2,5,7-tris(1,1-dimethylethyl)-L-tryptophan; Fmoc-L-Tryptophan(2,5,7-tri-tert-butyl)-OH; Fmoc-Trp(2,5,7-Tri-t-Bu)-OH; Nα-Fmoc-2,5,7-tri-tert-butyl-L-tryptophan; Fmoc-L-Trp(2,5,7-Tri-tert-butyl)-OH; Fmoc-Tryptophan(2,5,7-tri-tert-butyl)
EINECS	Contact for details

Quality Control

Our Fmoc-2,5,7-Tri-2,5,7-Tris-tert-Butyl-L-Tryptophan is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and correct stereochemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.