Description

n-[(1S)-3-Oxo-1-Phenylpropyl]-Carbamic Acid Phenylmethyl Ester CAS NO 376348-79-7 is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound matters because it provides a critical, stereochemically defined building block for the development of novel active pharmaceutical ingredients (APIs). Pharmaceutical R&D and manufacturing teams need it for the efficient and scalable production of complex therapeutic molecules, particularly in areas requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of complex drug candidates.
• API Development: Used in research and process development for new active pharmaceutical ingredients, especially those targeting neurological or metabolic disorders.
• Asymmetric Synthesis: Employed in reactions requiring high enantioselectivity to construct molecules with specific biological activity.
• Peptidomimetic Research: Acts as a precursor in the design and synthesis of peptide-like compounds for drug discovery.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the production of clinical trial materials and commercial APIs.
• Academic & Industrial R&D: Utilized in research laboratories for methodological studies in organic and medicinal chemistry.

Basic Information

Product Name	n-[(1S)-3-Oxo-1-Phenylpropyl]-Carbamic Acid Phenylmethyl Ester
CAS No.	376348-79-7
Molecular Formula	C17H17NO3
Molecular Weight	283.32 g/mol
Synonyms	(S)-3-Oxo-1-phenylpropyl carbamic acid benzyl ester; Benzyl N-[(1S)-3-oxo-1-phenylpropyl]carbamate; (S)-Benzyl (3-oxo-1-phenylpropyl)carbamate; (S)-Benzyl 3-oxo-1-phenylpropylcarbamate; (1S)-3-Oxo-1-phenylpropyl-carbamic acid phenylmethyl ester; (S)-Benzyloxycarbonylamino-1-phenyl-propan-3-one; Z-L-Phe-ψ[CH2CO] (depsipeptide analog intermediate); Chiral β-keto carbamate intermediate.
EINECS	Contact for details

Quality Control

Our n-[(1S)-3-Oxo-1-Phenylpropyl]-Carbamic Acid Phenylmethyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. Quality is verified through comprehensive analytical techniques including HPLC, chiral analysis, and NMR spectroscopy. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere if specified. Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.