Description

2,3,6-Trifluoromandelic Acid is a fluorinated mandelic acid derivative, a high-value chiral building block in advanced organic synthesis. Its unique trifluoromethyl-substituted aromatic structure makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals with enhanced metabolic stability and bioavailability. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorine atoms for property modulation.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and pesticides where fluorine substitution improves lipophilicity and target binding.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands used in asymmetric catalysis, such as in hydrogenation or cross-coupling reactions.
• Advanced Material Research: Employed in the synthesis of fluorinated liquid crystals or polymers for electronic and optical applications.
• Chemical Biology Probes: Useful for creating fluorinated analogs of biological molecules to study enzyme mechanisms and metabolic pathways.

Basic Information

Product Name	2,3,6-Trifluoromandelic Acid
CAS No.	374633-23-5
Molecular Formula	C8H5F3O3
Molecular Weight	206.12 g/mol
Synonyms	2,3,6-Trifluoro-α-hydroxybenzenacetic Acid; (2,3,6-Trifluorophenyl)(hydroxy)acetic Acid; α-Hydroxy-2,3,6-trifluorophenylacetic Acid; DL-2,3,6-Trifluoromandelic Acid; (±)-2,3,6-Trifluoromandelic Acid; 2,3,6-Trifluorobenzeneacetic acid, α-hydroxy-; Mandelic acid, 2,3,6-trifluoro-
EINECS	Contact for details

Quality Control

Our 2,3,6-Trifluoromandelic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the stringent requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its acidic nature, keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.