Description

Benzonitrile, 4-[(1R,2R)-2-Ethoxycyclopropyl]-, Rel- (9Ci) is a chiral, substituted benzonitrile derivative featuring a unique ethoxycyclopropyl moiety, serving as a sophisticated advanced pharmaceutical intermediate (API) and a versatile chiral building block for complex organic synthesis. Its stereochemically defined structure is critical for imparting specific biological activity and selectivity in the development of novel active ingredients. This high-value compound is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of targeted therapeutics and specialty agrochemicals.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Chiral Ligand & Catalyst Synthesis: Used to construct complex, enantiomerically pure ligands for asymmetric catalysis.
• Agrochemical Research: Serves as a building block for developing new-generation, stereospecific pesticides and herbicides.
• Material Science: Potential monomer or additive for creating specialized polymers with unique optical or electronic properties.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies in stereoselective synthesis.

Basic Information

Item	Details
Product Name	Benzonitrile, 4-[(1R,2R)-2-Ethoxycyclopropyl]-, Rel- (9Ci)
CAS No.	374081-52-4
Molecular Formula	C12H13NO
Molecular Weight	187.24 g/mol
Synonyms	4-[(1R,2R)-2-Ethoxycyclopropyl]benzonitrile; rel-(1R,2R)-2-(4-Cyanophenyl)cyclopropylethyl ether; (1R,2R)-2-(4-Cyanophenyl)cyclopropyl ethyl ether; 4-[(1R,2R)-2-Ethoxycyclopropyl]benzonitrile (rel-); Benzonitrile, 4-[(1R,2R)-2-ethoxycyclopropyl]-, (rel)-; 374081-52-4; (rel)-(1R,2R)-2-(4-Cyanophenyl)cyclopropylethyl ether
EINECS	Contact for details

Quality Control

Every batch of this high-purity chiral intermediate is produced under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing identity, purity (typically by HPLC), enantiomeric excess (by chiral HPLC), and impurity profiles to ensure it meets the stringent requirements of pharmaceutical development. Our quality assurance protocols are designed to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.