Description

4-Trifluoromethyl-Piperidin-4-Ol CAS NO 373603-69-1 is a high-value, fluorinated piperidine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring a trifluoromethyl group and a hydroxyl moiety on the same carbon, makes it a versatile intermediate for modulating the physicochemical properties of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of central nervous system (CNS) active drugs, protease inhibitors, and other bioactive molecules where the trifluoromethyl group is used to fine-tune lipophilicity and binding affinity.
• Agrochemical Synthesis: Employed in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the fluorine atoms to improve compound stability and membrane permeability.
• Ligand and Catalyst Development: Used in organometallic chemistry and catalysis research to create novel chiral ligands or metal complexes for asymmetric synthesis.
• Material Science Precursor: Acts as a functional monomer or cross-linking agent in the synthesis of specialty polymers and advanced materials with specific surface properties.
• Chemical Biology Probe: Utilized in medicinal chemistry and chemical biology to create molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Fluorine Chemistry Research: Serves as a standard or starting material in academic and industrial laboratories focused on exploring new methodologies in fluorine chemistry.

Basic Information

Product Name	4-Trifluoromethyl-Piperidin-4-Ol
CAS No.	373603-69-1
Molecular Formula	C7H12F3NO
Molecular Weight	183.17 g/mol
Synonyms	4-(Trifluoromethyl)piperidin-4-ol; 4-Hydroxy-4-(trifluoromethyl)piperidine; 4-Piperidinol, 4-(trifluoromethyl)-; α,α,α-Trifluoro-4-piperidinol; 4-Trifluoromethyl-4-hydroxypiperidine; 4-Trifluoromethyl-4-piperidinol
EINECS	Contact for details

Quality Control

Our 4-Trifluoromethyl-Piperidin-4-Ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.