Description

3-(9 H-Fluoren-9-Ylmethoxycarbonylamino)-3-Pyridin-4-Yl-Propionic Acid is a specialized Fmoc-protected amino acid derivative, a critical building block in modern solid-phase peptide synthesis (SPPS). Its core value lies in enabling the precise and efficient construction of complex peptides containing the 3-(4-pyridyl)-alanine residue, which is valuable for introducing specific structural and functional motifs. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and advanced materials science who require reliable, high-quality raw materials for their synthetic workflows.

Application

• As a key Fmoc-protected unnatural amino acid building block in Solid-Phase Peptide Synthesis (SPPS).
• For the research and production of therapeutic peptides and peptidomimetics containing the 3-(4-pyridyl)-alanine side chain.
• In the synthesis of peptide-based drug candidates targeting various diseases, where the pyridyl moiety can influence binding affinity and pharmacokinetics.
• For the development of conjugated peptides used in diagnostic imaging or targeted drug delivery systems.
• As a specialized intermediate in combinatorial chemistry libraries for high-throughput screening in drug discovery.
• In academic and industrial research for studying protein-protein interactions and enzyme mechanisms by incorporating this modified amino acid.

Basic Information

Product Name	3-(9 H-Fluoren-9-Ylmethoxycarbonylamino)-3-Pyridin-4-Yl-Propionic Acid
CAS No.	372144-23-5
Molecular Formula	C23H20N2O4
Molecular Weight	388.42 g/mol
Synonyms	Fmoc-3-(4-pyridyl)-L-alanine-OH; Fmoc-3-(4-Pyridyl)alanine; Fmoc-Pya-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(4-pyridinyl)-L-alanine; 3-(4-Pyridinyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(pyridin-4-yl)propanoic acid; Fmoc-L-3-(4-Pyridyl)alanine; Fmoc-β-(4-Pyridyl)-L-alanine
EINECS	Contact for details

Quality Control

Our 3-(9 H-Fluoren-9-Ylmethoxycarbonylamino)-3-Pyridin-4-Yl-Propionic Acid is manufactured under strict quality control protocols to ensure it meets the high-purity standards required for peptide synthesis. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR, and mass spectrometry for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.