Description

2-Chloro-4-(Hydroxymethyl)Benzonitrile is a versatile aromatic nitrile building block characterized by its chloro and hydroxymethyl functional groups. This compound is valued for its bifunctional reactivity, serving as a key intermediate in the synthesis of more complex molecules. It is primarily sought after by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for constructing active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, leveraging its aromatic core for bioactivity.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing advanced organic electronic materials and liquid crystal display (LCD) components.
• Polymer & Resin Modifier: Incorporated into specialty polymers to introduce cyanide and hydroxyl functionalities, altering material properties like adhesion and thermal stability.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic substitutions to create complex heterocycles and fine chemicals.
• Dye & Pigment Intermediate: Acts as a key component in the production of specialized dyes and colorants for industrial applications.

Basic Information

Product Name	2-Chloro-4-(Hydroxymethyl)Benzonitrile
CAS No.	371764-78-2
Molecular Formula	C8H6ClNO
Molecular Weight	167.59 g/mol
Synonyms	4-(Chloromethyl)-2-hydroxybenzonitrile; 2-Chloro-4-(hydroxymethyl)benzonitrile; 4-(Hydroxymethyl)-2-chlorobenzonitrile; 2-Chloro-4-(hydroxymethyl)phenyl cyanide; Benzonitrile, 2-chloro-4-(hydroxymethyl)-; (2-Chloro-4-cyanophenyl)methanol; 2-Chloro-4-cyanobenzyl alcohol
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-(Hydroxymethyl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for critical B2B supply chains.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. The compound may be hygroscopic; ensure containers are sealed under an inert atmosphere if specified for high-purity grades.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.