Description

(1R,6S)-8-Boc-3,8-Diazabicyclo[4.2.0]Octane CAS NO 370881-22-4 is a high-purity, stereochemically defined bicyclic amine derivative, specifically protected with a tert-butoxycarbonyl (Boc) group. This compound serves as a critical chiral building block and advanced pharmaceutical intermediate for the synthesis of complex bioactive molecules. It is primarily required by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization due to its rigid, three-dimensional bicyclic scaffold.
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand precursor in catalytic asymmetric transformations.
• Process Chemistry: Serves as a starting material or intermediate in the scale-up and commercial route development for active pharmaceutical ingredients (APIs).
• Chemical Biology: Utilized in the design and synthesis of molecular probes for studying biological targets and pathways.
• Academic Research: A valuable reagent for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	(1R,6S)-8-Boc-3,8-Diazabicyclo[4.2.0]Octane
CAS No.	370881-22-4
Molecular Formula	C12H22N2O2
Molecular Weight	226.32 g/mol
Synonyms	(1R,6S)-8-(tert-Butoxycarbonyl)-3,8-diazabicyclo[4.2.0]octane; tert-Butyl (1R,6S)-3,8-diazabicyclo[4.2.0]octane-8-carboxylate; (1R,6S)-8-Boc-3,8-diazabicyclo[4.2.0]octane; Boc-3,8-Diazabicyclo[4.2.0]octane, (1R,6S)-; (1R,6S)-Boc-DABCO derivative; (1R,6S)-endo-Boc-3,8-Diazabicyclo[4.2.0]octane; Chiral Boc-protected diazabicyclooctane
EINECS	Contact for details

Quality Control

Our (1R,6S)-8-Boc-3,8-Diazabicyclo[4.2.0]Octane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.