Description

(E)-3-(3-Bromo-4-Fluorophenyl)Acrylic Acid CAS NO 370867-85-9 is a high-purity, halogenated cinnamic acid derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents on the aromatic ring, makes it an exceptionally versatile intermediate for constructing complex molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and anti-inflammatory agent research.
• Agrochemical Synthesis: Used to construct advanced active ingredients for crop protection products, leveraging the bioactivity of the halogenated phenylacrylic scaffold.
• Liquid Crystal & OLED Material Development: Serves as a core building block for creating specialized fluorinated and brominated organic electronic materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed Suzuki, Heck, and Sonogashira cross-coupling reactions.
• Peptide Mimetics & Bioconjugation: The carboxylic acid functionality allows for amide bond formation, useful in creating peptide analogs and linker molecules.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D exploring new synthetic methodologies and material properties.

Basic Information

Product Name	(E)-3-(3-Bromo-4-Fluorophenyl)Acrylic Acid
CAS No.	370867-85-9
Molecular Formula	C9H6BrFO2
Molecular Weight	245.05 g/mol
Synonyms	(E)-3-(3-Bromo-4-fluorophenyl)-2-propenoic acid; trans-3-(3-Bromo-4-fluorophenyl)acrylic acid; 3-(3-Bromo-4-fluorophenyl)propenoic acid; 3-Bromo-4-fluorocinnamic acid; (E)-3-(3-Bromo-4-fluorophenyl)acrylic acid; 2-Propenoic acid, 3-(3-bromo-4-fluorophenyl)-, (E)-; 370867-85-9; (E)-3-(3-Bromo-4-fluorophenyl)prop-2-enoic acid
EINECS	Contact for details

Quality Control

Our production of (E)-3-(3-Bromo-4-Fluorophenyl)Acrylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, NMR, and GC-MS to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP-compliant manufacturing for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.