Description

(2R)-4-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-2-[[(Phenylmethoxy)Carbonyl]Amino]Butanoic Acid is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound matters because it provides critical orthogonality in Fmoc/Boc solid-phase peptide synthesis (SPPS), enabling the precise construction of complex peptides and proteins. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic research institutions developing therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block in Fmoc/Boc chemistry for the controlled assembly of peptide chains.
• Pharmaceutical Intermediates: Synthesis of active pharmaceutical ingredients (APIs) for peptide-based therapeutics targeting metabolic disorders, oncology, and CNS diseases.
• Bioconjugation & Labeling: Used to introduce functional handles or protected amino groups into biomolecules for further chemical modification.
• Research & Development: Critical reagent in academic and industrial labs for studying protein structure-function relationships and developing new bioactive compounds.
• Peptidomimetic Design: Serves as a scaffold for creating non-natural peptide analogs with enhanced stability and bioavailability.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	(2R)-4-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-2-[[(Phenylmethoxy)Carbonyl]Amino]Butanoic Acid
CAS No.	369611-58-5
Molecular Formula	C27H26N2O6
Molecular Weight	474.51 g/mol
Synonyms	Fmoc-D-Dab(Z)-OH; (2R)-4-[(9H-Fluoren-9-ylmethoxycarbonyl)amino]-2-[(benzyloxycarbonyl)amino]butanoic acid; Fmoc-D-Dab(Boc)-OH (common mis-assignment); D-Dab(Fmoc)-D-Dab(Z)-OH precursor; Nα-Fmoc-Nγ-Z-D-2,4-diaminobutyric acid; Fmoc-D-Dab(Z)-OH; Protected D-Diaminobutyric Acid derivative; Nγ-Fmoc-Nα-Z-D-2,4-diaminobutyric acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized by HPLC, NMR, and MS to confirm identity and purity, meeting the stringent requirements for pharmaceutical R&D and process development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.