Description

(3,4-Dichloro-Phenyl)-[(9H-Fluoren-9-Ylmethoxycarbonylamino)]-Acetic Acid CAS NO 369403-36-1 is a specialized Fmoc-protected amino acid derivative, a critical building block in modern solid-phase peptide synthesis (SPPS). Its primary value lies in enabling the controlled and efficient incorporation of a modified phenylalanine residue into complex peptide sequences. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid derivative for the automated synthesis of custom and complex peptides.
• Pharmaceutical Research & Development: Used in the discovery and development of new peptide drugs, including hormone analogs and enzyme inhibitors.
• Peptide Library Construction: Essential for creating combinatorial libraries for high-throughput screening in drug discovery campaigns.
• Bioconjugation & Labeling: Serves as a precursor for synthesizing peptide conjugates used in targeted drug delivery and diagnostic imaging.
• Chemical Biology Probes: Incorporated into peptides designed to study protein-protein interactions and cellular signaling pathways.
• API Intermediate Manufacturing: A critical raw material in the cGMP production of active pharmaceutical ingredients (APIs) for peptide therapeutics.

Basic Information

Product Name	(3,4-Dichloro-Phenyl)-[(9H-Fluoren-9-Ylmethoxycarbonylamino)]-Acetic Acid
CAS No.	369403-36-1
Molecular Formula	C23H17Cl2NO4
Molecular Weight	442.29 g/mol
Synonyms	Fmoc-3,4-dichloro-DL-phenylalanine; Fmoc-(3,4-Cl2)-DL-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,4-dichloro-DL-phenylalanine; N-Fmoc-3,4-dichlorophenylalanine; (3,4-Dichlorophenyl)-[(9H-fluoren-9-ylmethoxycarbonyl)amino]acetic acid; Fmoc-DL-3,4-dichlorophenylalanine; N-α-Fmoc-3,4-dichloro-DL-phenylalanine
EINECS	Contact for details

Quality Control

Our (3,4-Dichloro-Phenyl)-[(9H-Fluoren-9-Ylmethoxycarbonylamino)]-Acetic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements of pharmaceutical R&D and cGMP manufacturing. Certificates of Analysis (COA) with detailed chromatographic data are provided for full traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.