Description

Cyclopentanecarboxylic Acid, 1-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-3-Hydroxy- (9Ci) is a specialized Fmoc-protected amino acid derivative, a critical building block in modern solid-phase peptide synthesis (SPPS). Its value lies in enabling the precise and efficient construction of complex peptide sequences, particularly those requiring the incorporation of a cyclopentane ring and a hydroxyl group for structural diversity and bioactivity. This high-purity intermediate is essential for research and development in pharmaceutical discovery, biotechnology, and advanced materials science, where it is used to create novel therapeutic peptides, peptidomimetics, and bioactive probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated, sequential assembly of custom peptide chains in pharmaceutical R&D.
• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetic Design: Used to create non-natural peptide analogs where the cyclopentane ring introduces conformational constraints to enhance stability, potency, and selectivity.
• Bioconjugation & Probe Development: Facilitates the site-specific introduction of functional handles into peptides for labeling, imaging, or creating peptide-drug conjugates.
• Academic & Industrial Research: A vital reagent for studying protein-protein interactions, enzyme substrates/inhibitors, and structure-activity relationships (SAR) in life sciences.
• Combinatorial Chemistry Libraries: Employed to generate diverse libraries of cyclic and constrained peptides for high-throughput screening in drug discovery.

Basic Information

Item	Details
Product Name	Cyclopentanecarboxylic Acid, 1-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-3-Hydroxy- (9Ci)
CAS No.	369403-17-8
Molecular Formula	C21H21NO5
Molecular Weight	367.40 g/mol
Synonyms	Fmoc-3-Hydroxy-cyclopentanecarboxylic acid; Fmoc-Cpa(3-OH)-OH; 1-(Fmoc-amino)-3-hydroxycyclopentanecarboxylic acid; (1S,3S)-1-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-hydroxycyclopentanecarboxylic acid; Fmoc-3-hydroxy-1-aminocyclopentanecarboxylic acid; N-α-Fmoc-3-hydroxycyclopentylglycine; Protected amino acid 369403-17-8
EINECS	Contact for details

Quality Control

Our Cyclopentanecarboxylic Acid, 1-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-3-Hydroxy- (9Ci) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere (argon or nitrogen) after each use to maintain stability and prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (specify isomer)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.