Description

Olmesartan Acid o-β-D-Glucuronide is a key metabolite and reference standard of the antihypertensive drug Olmesartan medoxomil. This compound is critical for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in cardiovascular drug development and regulatory compliance testing.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantitative and qualitative analysis of Olmesartan and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, bioavailability, and excretion profiles of Olmesartan medoxomil.
• Bioanalytical Method Development: Used as a critical standard in developing and validating HPLC, LC-MS, and LC-MS/MS methods for clinical and preclinical studies.
• Impurity Profiling and Characterization: Employed to identify and quantify process-related impurities and degradation products in active pharmaceutical ingredient (API) batches.
• Regulatory Submission Support: Provides essential data for regulatory filings (e.g., FDA, EMA) requiring detailed metabolite identification and safety assessments.

Basic Information

Product Name	Olmesartan Acid o-β-D-Glucuronide
CAS No.	369395-57-3
Molecular Formula	C30H34N6O10
Molecular Weight	614.63 g/mol
Synonyms	Olmesartan glucuronide; Olmesartan acyl-β-D-glucuronide; (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-imidazole-5-carboxylate β-D-glucopyranosiduronic acid; Olmesartan M-I; RNH-6270 glucuronide; CS-866 metabolite
EINECS	Contact for details

Quality Control

Our Olmesartan Acid o-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, LC-MS for identity confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical reference standards. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. This hygroscopic and light-sensitive compound should be handled under inert conditions and allowed to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.