Description

4-Ethynyl-Benzo[1,3]Dioxole (CAS NO 369363-94-0) is a high-value, functionalized aromatic building block featuring both an ethynyl group and a 1,3-benzodioxole moiety. This unique bifunctional structure makes it a critical intermediate for synthesizing complex molecules in advanced research and development. It is primarily sought after by pharmaceutical, agrochemical, and materials science industries for applications in drug discovery, ligand synthesis, and the creation of novel polymers or functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new active pharmaceutical ingredients (APIs), particularly in oncology and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and plant growth regulators.
• Materials Science: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers, conductive materials, and metal-organic frameworks (MOFs).
• Chemical Biology & Proteomics: Employed as a click chemistry handle (via the alkyne group) for bioconjugation, labeling biomolecules, and developing chemical probes.
• Ligand & Catalyst Development: Utilized to create novel ligands for catalysis and organometallic chemistry applications.
• Academic & Industrial R&D: A versatile building block for exploratory organic synthesis and method development in research laboratories.

Basic Information

Item	Details
Product Name	4-Ethynyl-Benzo[1,3]Dioxole
CAS No.	369363-94-0
Molecular Formula	C9H6O2
Molecular Weight	146.14 g/mol
Synonyms	4-Ethynyl-1,3-benzodioxole; 5-Ethynylbenzo[d][1,3]dioxole; 4-Ethynylbenzo-1,3-dioxole; 1,3-Benzodioxole, 4-ethynyl-; 4-Ethynyl-2H-1,3-benzodioxole
EINECS	Contact for details

Quality Control

Our 4-Ethynyl-Benzo[1,3]Dioxole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). The compound is light-sensitive and should be handled under an inert atmosphere for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.