Description

Cyclobutaneacetonitrile, 3-Acetyl-2,2-Dimethyl-, (1R,3S)-Rel- (9Ci) is a high-purity, stereochemically defined chiral intermediate of significant interest in advanced organic synthesis. Its value lies in its complex cyclobutane-acetonitrile core, which serves as a versatile building block for constructing novel molecular architectures with precise three-dimensional control. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of new active ingredients where specific stereochemistry is critical for biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially in medicinal chemistry programs targeting complex small molecules.
• Agrochemical Synthesis: Used in the creation of novel, stereoselective pesticides and herbicides where the specific (1R,3S) configuration can influence efficacy and environmental profile.
• Advanced Material Research: Serves as a precursor for specialty polymers or liquid crystals where the rigid cyclobutane ring contributes to desired material properties.
• Asymmetric Catalysis Ligand Precursor: Potential use in the synthesis of novel chiral ligands or organocatalysts for enantioselective transformations.
• Chemical Biology Probes: Useful for synthesizing labeled or tagged compounds to study biological pathways and interactions.
• Academic & Industrial R&D: A valuable tool for methodological development in organic synthesis, particularly in studies involving cyclobutane chemistry and stereocontrol.

Basic Information

Product Name	Cyclobutaneacetonitrile, 3-Acetyl-2,2-Dimethyl-, (1R,3S)-Rel- (9Ci)
CAS No.	368423-20-5
Molecular Formula	C10H15NO
Molecular Weight	165.23 g/mol
Synonyms	(1R,3S)-rel-3-Acetyl-2,2-dimethylcyclobutaneacetonitrile; rel-(1R,3S)-3-Acetyl-2,2-dimethylcyclobutan-1-ylacetonitrile; 3-Acetyl-2,2-dimethylcyclobutaneacetonitrile, (1R,3S)-rel-; 2,2-Dimethyl-3-acetylcyclobutaneacetonitrile, (1R,3S)-rel-; Cyclobutanacetonitrile, 3-acetyl-2,2-dimethyl-, (1R,3S)-rel-; (1R,3S)-3-Acetyl-2,2-dimethylcyclobutan-1-ylacetonitrile (relative configuration); 368423-20-5; (rel)-(1R,3S)-3-Acetyl-2,2-dimethylcyclobutaneacetonitrile
EINECS	Contact for details

Quality Control

Our Cyclobutaneacetonitrile, 3-Acetyl-2,2-Dimethyl-, (1R,3S)-Rel- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure high chemical and isomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. For long-term storage, maintaining the material at 2-8°C under an inert atmosphere is recommended to preserve stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.