Description

L-Proline, 1-Cyano-, Methyl Ester (9Ci) is a high-purity, non-proteinogenic amino acid derivative, specifically a cyano-substituted proline methyl ester. This compound serves as a versatile and critical chiral building block in advanced organic synthesis, enabling the construction of complex molecular architectures with precise stereocontrol. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for applications in medicinal chemistry, peptide mimetics, and catalyst development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly protease inhibitors and other biologically active molecules.
• Peptidomimetics Research: Used to introduce constrained proline analogs into peptide backbones to enhance metabolic stability and receptor selectivity.
• Agrochemical Synthesis: Employed in the development of advanced, enantiomerically pure pesticides and herbicides.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands and organocatalysts used in stereoselective transformations.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes and molecular tools for studying enzyme function.
• Academic & Industrial R&D: A fundamental reagent for methodological development in organic chemistry and material science research.

Basic Information

Product Name	L-Proline, 1-Cyano-, Methyl Ester (9Ci)
CAS No.	367906-51-2
Molecular Formula	C7H10N2O2
Molecular Weight	154.17 g/mol
Synonyms	(2S)-1-Cyano-2-pyrrolidinecarboxylic acid methyl ester; Methyl (2S)-1-cyanopyrrolidine-2-carboxylate; L-1-Cyanoproline methyl ester; (S)-1-Cyanopyrrolidine-2-carboxylic acid methyl ester; Methyl L-1-cyanoproline; 1-Cyano-L-proline methyl ester; Proline, 1-cyano-, methyl ester, L-; Methyl 1-cyanopyrrolidine-2-carboxylate
EINECS	Contact for details

Quality Control

Our L-Proline, 1-Cyano-, Methyl Ester (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing identity, purity (typically >97%), and impurity profiles are provided with every shipment to guarantee batch-to-batch consistency and reliable performance in your applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.