Description

2-Ethynyl-1,3,5-Trifluoro-Benzene is a high-purity, multi-functional aromatic building block characterized by its unique combination of an ethynyl group and fluorine substituents. This compound is critical for advanced organic synthesis, enabling the construction of complex molecular architectures through cross-coupling and cycloaddition reactions. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the development of active pharmaceutical ingredients (APIs), particularly for fluorine-containing drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the trifluoromethylphenyl moiety enhances biological activity and environmental stability.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Organic Light-Emitting Diodes (OLEDs): Employed in the fabrication of electron-transport layers and emissive materials due to its favorable electronic properties.
• Cross-Coupling Reactions: An excellent substrate for Sonogashira, Heck, and Suzuki-Miyaura couplings to introduce conjugated acetylene units into complex molecules.
• Click Chemistry: The terminal alkyne group facilitates efficient Huisgen 1,3-dipolar cycloaddition (click) reactions for bioconjugation and polymer functionalization.

Basic Information

Product Name	2-Ethynyl-1,3,5-Trifluoro-Benzene
CAS No.	366807-79-6
Molecular Formula	C8H3F3
Molecular Weight	156.11 g/mol
Synonyms	1,3,5-Trifluoro-2-ethynylbenzene; 2-Ethynyl-1,3,5-trifluorobenzene; 2-Ethynylbenzene-1,3,5-trifluoride; 1-Ethynyl-2,4,6-trifluorobenzene; (2,4,6-Trifluorophenyl)acetylene; 2,4,6-Trifluorophenylacetylene
EINECS	Contact for details

Quality Control

Our 2-Ethynyl-1,3,5-Trifluoro-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with every shipment, detailing all critical quality attributes. We adhere to cGMP principles where applicable, ensuring reliable supply for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) to prevent moisture absorption and degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.