Description

Ethyl 2-Amino-2-(4-Fluorophenyl)Acetate is a high-purity fluorinated amino acid ester derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a versatile scaffold for constructing complex molecules with a fluorine atom, which is essential for modulating biological activity and physicochemical properties. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs), drug candidates, and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and production of fluorinated drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Building block for developing novel fluorinated pesticides and herbicides, where the fluorine atom enhances stability and bioactivity.
• Peptidomimetics Research: Used in the design and synthesis of peptide analogs and mimetics to improve metabolic stability and binding affinity.
• Asymmetric Catalysis: Employed as a substrate or ligand precursor in asymmetric synthesis to create enantiomerically pure compounds.
• Chemical Biology Probes: Utilized in the development of fluorinated probes and tags for studying biological mechanisms and protein interactions.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	Ethyl 2-Amino-2-(4-Fluorophenyl)Acetate
CAS No.	366018-91-9
Molecular Formula	C₁₀H₁₂FNO₂
Molecular Weight	197.21 g/mol
Synonyms	Ethyl 2-Amino-2-(4-fluorophenyl)acetate; 2-Amino-2-(4-fluorophenyl)acetic acid ethyl ester; Ethyl (4-fluorophenyl)glycinate; (4-Fluorophenyl)glycine ethyl ester; DL-4-Fluorophenylglycine ethyl ester; Ethyl α-amino-4-fluorophenylacetate; 366018-91-9; Ethyl 2-amino-2-(p-fluorophenyl)acetate
EINECS	Contact for details

Quality Control

Our Ethyl 2-Amino-2-(4-Fluorophenyl)Acetate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity assessment, to meet the stringent requirements of pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (specify enantiomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.