Description

(R)-2-((tert-Butoxycarbonyl)Amino)-2-Phenylpropanoicacid CAS NO 365442-14-4 is a high-purity, non-natural amino acid derivative featuring a chiral center and a tert-butoxycarbonyl (Boc) protecting group. This compound is a critical chiral building block for the synthesis of complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutics, including peptidomimetics and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of APIs targeting central nervous system disorders, metabolic diseases, and oncology.
• Peptidomimetic Research: Used to incorporate non-natural, sterically hindered phenylalanine analogs into peptide chains to enhance stability, bioavailability, and biological activity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing chiral ligands and organocatalysts used in enantioselective transformations.
• Protease Inhibitor Development: Employed in the design and synthesis of inhibitors for various proteases due to its specific stereochemistry and functional groups.
• Chemical Biology Probes: Utilized to create labeled or modified amino acids for studying protein structure, function, and interactions.
• Fine Chemical Synthesis: Acts as a versatile building block for creating complex, high-value chiral molecules in custom synthesis and contract manufacturing.

Basic Information

Item	Detail
Product Name	(R)-2-((tert-Butoxycarbonyl)Amino)-2-Phenylpropanoicacid
CAS No.	365442-14-4
Molecular Formula	C14H19NO4
Molecular Weight	265.31 g/mol
Synonyms	(R)-2-(Boc-Amino)-2-phenylpropanoic acid; (R)-2-[(tert-Butoxycarbonyl)amino]-2-phenylpropanoic acid; (R)-Boc-Amino-2-phenylpropionic acid; (R)-N-Boc-2-amino-2-phenylpropionic acid; (R)-N-(tert-Butoxycarbonyl)-2-amino-2-phenylpropionic acid; (R)-2-Phenyl-2-[(tert-butoxycarbonyl)amino]propanoic acid; (R)-α-Methyl-N-Boc-phenylalanine; Boc-D-α-Me-Phe-OH
EINECS	Contact for details

Quality Control

Our (R)-2-((tert-Butoxycarbonyl)Amino)-2-Phenylpropanoicacid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.