Description

2,6-Bis[(4R)-Benzyl-2-Oxazolin-2-Yl]Pyridine is a chiral, C2-symmetric ligand belonging to the bis(oxazoline) family, a cornerstone in modern asymmetric synthesis. Its primary value lies in its ability to coordinate with various transition metals to form highly effective and selective catalysts for a wide range of enantioselective transformations. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control. The CAS number for this material is 365215-38-9.

Application

• Asymmetric Catalysis: As a privileged ligand for copper, palladium, nickel, and other transition metals in enantioselective reactions.
• Pharmaceutical Intermediate Synthesis: For the production of chiral active pharmaceutical ingredients (APIs) requiring high enantiomeric excess.
• Fine Chemical Manufacturing: Enabling asymmetric cyclopropanation, Diels-Alder, aldol, and Henry reactions.
• Agrochemical Development: In the synthesis of chiral herbicides, fungicides, and pesticides.
• Academic & Industrial R&D: A critical tool for developing new catalytic methodologies and exploring novel reaction pathways.
• Material Science: Potential use in creating chiral polymers or frameworks with specific optical properties.

Basic Information

Item	Details
Product Name	2,6-Bis[(4R)-Benzyl-2-Oxazolin-2-Yl]Pyridine
CAS No.	365215-38-9
Molecular Formula	C25H23N3O2
Molecular Weight	397.47 g/mol
Synonyms	(R,R)-2,6-Bis(4-benzyl-4,5-dihydrooxazol-2-yl)pyridine; (4R,4'R)-2,6-Bis(4-benzyl-4,5-dihydrooxazol-2-yl)pyridine; (R)-2,6-Bis(4-benzyl-2-oxazolin-2-yl)pyridine; PyBOX Ligand (R,R)-Bn; (R,R)-2,6-Bis(4-benzyl-2-oxazoliny)pyridine; (R,R)-Bn-PyBOX; Chiral Bis(oxazoline) Ligand
EINECS	Contact for details

Quality Control

Every batch of our 2,6-Bis[(4R)-Benzyl-2-Oxazolin-2-Yl]Pyridine is produced and tested under strict quality management systems. We ensure high chemical purity and enantiomeric excess (ee) critical for catalytic performance. Standard analytical techniques including HPLC, NMR, and chiral analysis are employed. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral purity is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container sealed in a desiccator or under an inert atmosphere for long-term storage to maintain stability and prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.