Description

Carbamic Acid, [(1R,2S)-2-Aminocyclohexyl]-, 1,1-Dimethylethyl Ester (9Ci) is a high-purity, chiral carbamate derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its role as a protected chiral amine intermediate, enabling the stereoselective construction of complex molecules. This compound is essential for research and development in the pharmaceutical industry, particularly for the synthesis of active pharmaceutical ingredients (APIs) and fine chemicals requiring precise stereochemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel therapeutic agents, including central nervous system (CNS) drugs and enzyme inhibitors.
• Asymmetric Synthesis: Used in the stereocontrolled synthesis of complex natural products and bioactive molecules where the (1R,2S)-2-aminocyclohexyl moiety is required.
• Peptidomimetics & Protease Inhibitors: Serves as a constrained scaffold in the design and synthesis of peptide mimics and inhibitors targeting specific proteases.
• Agrochemical Research: Employed in the discovery and synthesis of new chiral active ingredients for crop protection products.
• Catalyst & Ligand Development: Acts as a precursor for chiral ligands and organocatalysts used in enantioselective transformations.
• Academic & Process Chemistry: A valuable reagent for methodological development in academic laboratories and for scaling up synthetic routes in process chemistry.

Basic Information

Product Name	Carbamic Acid, [(1R,2S)-2-Aminocyclohexyl]-, 1,1-Dimethylethyl Ester (9Ci)
CAS No.	364385-54-6
Molecular Formula	C11H22N2O2
Molecular Weight	214.31 g/mol
Synonyms	(1R,2S)-N-(tert-Butoxycarbonyl)-1,2-diaminocyclohexane; (1R,2S)-N-Boc-1,2-diaminocyclohexane; tert-Butyl (1R,2S)-2-aminocyclohexylcarbamate; (1R,2S)-2-[(tert-Butoxycarbonyl)amino]cyclohexanamine; (1R,2S)-Boc-DACH; (1R,2S)-Boc-1,2-Diaminocyclohexane; (1R,2S)-trans-N-Boc-1,2-diaminocyclohexane; (1R,2S)-N-Boc-trans-1,2-diaminocyclohexane
EINECS	Contact for details

Quality Control

Our Carbamic Acid, [(1R,2S)-2-Aminocyhexyl]-, 1,1-Dimethylethyl Ester (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.