Description

(S)-(-)-2,2'-Bis[Di(3,5-Xylyl)Phosphino]-6,6'-Dimethoxy-1,1'-Biphenyl,Min.97% is a high-purity, chiral bisphosphine ligand, a critical component in asymmetric catalysis. Its value lies in enabling highly enantioselective transformations, which are essential for the efficient and cost-effective synthesis of single-enantiomer pharmaceuticals and fine chemicals. This product is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors who require precise stereochemical control in their synthetic processes.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, a cornerstone reaction in chiral API synthesis.
• Pharmaceutical Intermediate Synthesis: Key for constructing chiral centers in complex drug molecules, including cardiovascular, central nervous system (CNS), and antiviral agents.
• Agrochemical Production: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators for enhanced efficacy and environmental safety.
• Fine Chemical Manufacturing: Enables the production of chiral flavors, fragrances, and advanced materials with specific stereochemical properties.
• Catalyst Development & Screening: An essential tool for chemists in R&D for developing new catalytic systems and optimizing reaction conditions for maximum enantiomeric excess (ee).
• Academic & Industrial Research: Serves as a benchmark ligand in methodological studies and process chemistry development for asymmetric synthesis.

Basic Information

Product Name	(S)-(-)-2,2'-Bis[Di(3,5-Xylyl)Phosphino]-6,6'-Dimethoxy-1,1'-Biphenyl, Min. 97%
CAS No.	362634-22-8
Molecular Formula	C52H52O2P2
Molecular Weight	770.91 g/mol
Synonyms	(S)-(-)-DTBM-SEGPHOS; (S)-DTBM-SEGPHOS; (S)-5,5'-Bis[di(3,5-xylyl)phosphino]-4,4'-bi-1,3-benzodioxole; (S)-(-)-2,2'-Bis(bis(3,5-dimethylphenyl)phosphino)-6,6'-dimethoxy-1,1'-biphenyl; SEGPHOS-DTBM; DTBM-SEGPHOS Ligand; (S)-DTBM-SEGPHOS Ligand; (S)-3,3',5,5'-Tetra-tert-butyl-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (common misnomer, included for search relevance)
EINECS	Contact for details

Quality Control

Our (S)-DTBM-SEGPHOS is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high enantiomeric purity, critical for reproducible catalytic performance. Each lot is analyzed via HPLC, NMR (¹H and ³¹P), and optical rotation to confirm identity, chemical purity (≥97%), and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a freezer. This compound is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light will degrade its catalytic activity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	Min. 97.0%
Specific Optical Rotation	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.