Description

2-Propylpentanoic-D15 Acid is a deuterium-labeled analog of valproic acid, a compound of significant pharmacological interest. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring analytical accuracy and reliability. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and analytical service providers engaged in drug metabolism, pharmacokinetic (DMPK) studies, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of valproic acid and its metabolites in biological matrices (plasma, serum, urine) during bioanalytical assays.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of valproic acid.
• Therapeutic Drug Monitoring (TDM): Supports the development and validation of high-precision assays for monitoring valproic acid concentrations in patient samples.
• Isotope Dilution Mass Spectrometry (IDMS): Serves as a spike-in standard for this gold-standard quantitative technique, minimizing matrix effects and improving data accuracy.
• Pharmaceutical Reference Standard: Acts as a certified reference material for quality control and method validation in pharmaceutical development.
• Clinical Research: Facilitates reliable data generation in clinical trials involving valproic acid or related compounds.

Basic Information

Product Name	2-Propylpentanoic-D15 Acid
CAS No.	362049-65-8
Molecular Formula	C8D15HO2
Molecular Weight	149.27 g/mol (theoretical)
Synonyms	Valproic Acid-d15; 2-Propylpentanoic Acid-d15; Valproic-d15 Acid; Depakene-d15; Divalproex-d15; 2-Propyl-1,1,2,3,3,4,4,5,5,6,6,7,7,8,8-pentadeca-deuterio-pentanoic Acid; Pentadeuterated Valproic Acid
EINECS	Contact for details

Quality Control

Our 2-Propylpentanoic-D15 Acid is manufactured under controlled conditions to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm isotopic enrichment and chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical results is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its nature as a strong acid/organic solvent, keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0% (chemical purity)
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.